Opioid Induced Constipation?

Posted on November 19, 2017
Archive : November 2017
Category : News

Is this new treatment the solution?

New Formulation of Sustained Release Naloxone CAN Reverse Opioid Induced Constipation Without Compromising the Desired Opioid Effects 

Opioids are commonly prescribed for the treatment of acute and chronic pain. However one of their most common and distressing adverse effects is constipation, which occurs in 41% to 81% of patients taking opioids.

Studies have shown that Doctors rated constipation as a key issue associated with opioid use, which can lead to discontinuation or reduction in opioid treatment. Constipation also has a major impact on Quality of Life and is an additional impediment for chronic pain sufferers having to take opioids.

One of the challenges with opioid usage is that tolerance develops to the analgesic but not to the constipating effects of agonists on the colon .

The most common treatment for OIC involves stool softeners, bulk laxatives, and bowel stimulants, but despite aggressive use of laxatives patients with OIC find constipation persists, with only half achieving the desired results with standard therapy. Chronic use of bowel stimulants is also controversial as prolonged use can lead to dependency on the stimulant to produce laxation .

Naloxone has been described as the “gold standard” opioid antagonist, used to reverse the effects of opioids 

An international double-blind randomized placebo controlled study evaluated the safety and efficacy of four doses of a new sustained release naloxone capsule to treat Opioid Induced Constipation (OIC).

This Phase II study has shown that using a new sustained release formulation to deliver oral naloxone to the colon allows successful treatment of OIC without comprising the desired opioid effects.

If you would like more information on how to take part in this study then please register your interest below:

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Click here to read the full article:    Oxford Academic